Biosensor Research & Hardware Development

Xiaojun Yang, NanoSensor Researcher

Saxion University of Applied Sciences | Enschede, Netherlands

🏆 2024 Poster Prize Winner 📄 2 Journal Publications 💶 €80K Research Funding 🔬 Researcher (2022-2025)

Current Research Projects

Hardware development and applied research at Saxion University (2022 - 2025)

Micro-/Nanoparticle Sizing

Active

Electrochemical sensing platform for particle characterization

Developing a portable electrochemical system for sizing particles from 300 nm to 5 μm using ring ultra-microelectrodes and single-entity electrochemistry.

Funding:

Dutch SIA KIEM-GoChem (2024-2025) | €40,000

Applications:

  • • Medical diagnostics
  • • Environmental monitoring
  • • Quality control

MIP-Based PFAS Sensor

In Development

Environmental contamination detection platform

Molecular Imprinted Polymer (MIP) functionalized electrodes for sensitive PFAS detection in water and environmental samples.

Technology:

Electrochemical detection with artificial recognition elements

Target:

  • • Picomolar sensitivity
  • • Low-cost screening
  • • Point-of-need testing

SporeSpotter

2025-2026

SERS-based bacterial spore detection in milk

Surface-Enhanced Raman Scattering (SERS) platform for rapid detection of bacterial spores in dairy products.

Funding:

Dutch SIA KIEM-GoChem (2025-2026) | €40,000

Innovation:

  • • Particle-based SERS sensing
  • • Food safety application
  • • Rapid screening method

ORCHIDD Project

Industry Collab

Biosensor technology readiness enhancement

Collaboration with startup ECsens to enhance the technology readiness level (TRL) of electrochemical biosensor platforms.

Partner:

ECsens (Startup)

Focus:

  • • Prototype optimization
  • • Sensor validation
  • • Commercial readiness

Hardware & Technology Platforms

Affordable, high-performance sensing platforms for research and development

Point-of-Need Potentiostat

Low-cost, high-performance electrochemical measurement platform. Portable and versatile for field applications.

€199
  • ✓ Portable design
  • ✓ Multiple techniques
  • ✓ USB connectivity
  • ✓ Open-source compatible
Available
🔬

Functional Electrodes

MIP-functionalized screen-printed electrodes for specific molecule detection. Artificial recognition elements.

€20 /electrode
  • ✓ Custom MIP coating
  • ✓ High selectivity
  • ✓ Low cost
  • ✓ Various analytes
Available
📱

Wearable Dev-Kit

Complete development kit for wearable biosensors. Sweat analysis and continuous monitoring applications.

€249
  • ✓ Wireless connectivity
  • ✓ Real-time monitoring
  • ✓ Multiple sensors
  • ✓ Software included
In Development

Core Technologies

Cutting-edge sensing methodologies

Single-Entity Electrochemistry

Ring ultra-microelectrode (UME) technology enabling precise detection and sizing of individual micro- and nanoparticles.

Key Features:

  • • Single-particle resolution
  • • Size range: 300 nm - 5 μm
  • • Current-blockade detection
  • • Label-free measurement

Patent pending: "Electrochemical affinity biosensor for label-free detection using particle collision"

View Poster

MIP-Functionalized Electrodes

Molecularly Imprinted Polymers (MIPs) provide affordable, stable artificial recognition elements for selective molecule detection.

Applications:

  • • PFAS environmental monitoring
  • • Cortisol stress detection
  • • Sweat biomarker analysis
  • • Drug screening

Integrated with €100 potentiostat for affordable dev-kits

View Poster

Machine Learning & Data Analysis

Deep learning applications for biosensor signal processing

StepReaderCNN-MVP

CNN-Based Electrochemical Signal Classifier

Open Source

Deep learning framework for analyzing electrochemical sensor signals. The system classifies particles by size (1μm, 2μm, 3μm) using collision signal data from single-entity electrochemistry experiments, achieving 80% validation accuracy.

🧠 Technologies

  • • PyTorch 2.9.0 (3 CNN architectures)
  • • Streamlit web interface
  • • FastAPI backend
  • • NumPy, Pandas, SciPy
  • • TensorBoard visualization

🎯 Key Features

  • • 42 real CSV datasets (99K-153K points)
  • • Synthetic signal generation
  • • ResNet1D, SimpleCNN, MultiScale models
  • • 104.1 inferences/second
  • • Interactive data exploration

Performance: ResNet1D achieves 80% validation accuracy with ~29 second training time and 9.61ms inference latency

License: MIT License - Open source for academic research

Peer-Reviewed Publications

Research contributions to the field

Ring Ultramicroelectrodes for Current-Blockade Particle-Impact Electrochemistry

Taghi Moazzenzade, Tieme Walstra, Xiaojun Yang, Jurriaan Huskens, and Serge G. Lemay

Analytical Chemistry 2022, 94 (28), 10168-10174

DOI: 10.1021/acs.analchem.2c01503 →

Self-Induced Convection at Microelectrodes: Its Influence on Impact Electrochemistry

Taghi Moazzenzade, Xiaojun Yang, Luc Walterbos, Jurriaan Huskens, Christophe Renault, and Serge G. Lemay

Journal of the American Chemical Society 2020, 142 (42), 17908-17912

DOI: 10.1021/jacs.0c08450 →

Sensing Micro-/Nanoparticles on Nano-ring Electrodes

Poster presentation at the 2024 Dutch Micro-Nano Conference

Xiaojun Yang, Saxion University of Applied Sciences

View Poster
🏆 Poster Prize

Research Collaboration Opportunities

Open to partnerships in biosensor development, applied nanotechnology, and point-of-care diagnostics

🤝 Academic Collaborations

  • • Joint research projects
  • • Co-authored publications
  • • PhD/Master supervision
  • • Grant applications (EU Horizon, NWO)

🏢 Industry Partnerships

  • • Technology transfer projects
  • • Custom sensor development
  • • Prototype validation
  • • Technical consulting

🔬 Hardware Integration

  • • Custom electrode development
  • • Potentiostat integration
  • • Sensing platform optimization
  • • Early access to dev-kits

🎓 Student Projects

  • • Master thesis supervision
  • • Internship opportunities
  • • Research training
  • • Hands-on experience

Response time: typically within 48 hours

Academic Profile & Expertise

🎓 Education

  • M.Sc. Applied Nanotechnology

    Saxion University (2018-2020)

  • M.Sc. Mechanical Engineering

    Shanghai Jiao Tong University (2012-2015)

  • HarvardX MCB63X

    Biochemistry (2023)

🛠️ Technical Skills

  • • Electrochemistry & biosensors
  • • Nanofabrication (MEMS/NEMS)
  • • COMSOL, Ansys simulation
  • • Python, MATLAB, LabVIEW
  • • SolidWorks (CAD/prototyping)
  • • Data analysis & modeling

💼 Research Experience

  • Saxion University (2022-2025)

    Biosensor researcher

  • University of Twente (2020-2021)

    Internship researcher

  • Machine Learning for Data Analysis

    CNN-based signal processing